Antihistamine (Allergy)Generally Approved24h wait period

Cetirizine

Brand names: Zyrtec|Last verified: 2026-03-01

FAA Pathway: Acceptable with wait period after each dose

Cetirizine is an acceptable second-generation antihistamine for pilots. However, the FAA requires a grounding period after each dose to ensure no sedating side effects before flying.

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Related Resources

Pilot Tip

Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.

Certification Details

Wait Period

Must wait at least a full dose cycle (typically 24 hours) plus observation

Certificate Classes

All classes eligible

Better Alternative

Loratadine (Claritin) has a shorter recommended wait

Notes

First-generation antihistamines (Benadryl) are NOT acceptable for flying

Sources

FAA OTC Medication Guide, Allergy

Last verified: 2026-03-01

Frequently Asked Questions

Is Cetirizine allowed for pilots?

The FAA considers Cetirizine (Zyrtec) to be "Generally Approved" for medical certification purposes. Cetirizine is an acceptable second-generation antihistamine for pilots. However, the FAA requires a grounding period after each dose to ensure no sedating side effects before flying.

What is the FAA status of Cetirizine?

Cetirizine has a status of "Generally Approved" under FAA medical certification policy. The certification pathway is: Acceptable with wait period after each dose.

Can I fly while taking Cetirizine?

Cetirizine is generally compatible with flying. However, you must report it on your FAA medical application (Form 8500-8) and ensure you are not experiencing side effects that could impair flight safety. Always consult your Aviation Medical Examiner (AME).

Important Notice

The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.

The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.