SGLT2 Inhibitor (Type 2 Diabetes)Conditionally Approved

Empagliflozin

Brand names: Jardiance|Last verified: 2026-03-01

FAA Pathway: Special Issuance (Diabetes Protocol)

Empagliflozin is an SGLT2 inhibitor that may be approved for pilots with Type 2 diabetes through the Special Issuance process. While it has cardiovascular benefits, the FAA requires documentation of stable glucose control and absence of diabetic ketoacidosis risk.

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Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.

Certification Details

Key Requirements
A1C monitoring, no DKA episodes, glucose stability
Certificate Classes
1st, 2nd, and 3rd class eligible
Monitoring
Quarterly A1C, renal function monitoring
Notes
SGLT2 inhibitors carry DKA risk — must be documented as absent

Sources

  • FAA AME Guide — Pharmaceuticals: Diabetes Type II (faa.gov/ame_guide/pharm/oral_diabetes)

Last verified: 2026-03-01

Frequently Asked Questions

Is Empagliflozin allowed for pilots?

The FAA considers Empagliflozin (Jardiance) to be "Conditionally Approved" for medical certification purposes. Empagliflozin is an SGLT2 inhibitor that may be approved for pilots with Type 2 diabetes through the Special Issuance process. While it has cardiovascular benefits, the FAA requires documentation of stable glucose control and absence of diabetic ketoacidosis risk.

What is the FAA status of Empagliflozin?

Empagliflozin has a status of "Conditionally Approved" under FAA medical certification policy. The certification pathway is: Special Issuance (Diabetes Protocol).

Can I fly while taking Empagliflozin?

Flying while taking Empagliflozin may be possible through the FAA's Special Issuance process. You will need to meet specific requirements and obtain approval before exercising pilot privileges. Consult an experienced AME for guidance.

Important Notice

The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.

The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.