AntifungalGenerally Approved

Fluconazole

Brand names: Diflucan|Last verified: 2026-03-01

FAA Pathway: Generally acceptable for short-term use

Fluconazole is generally acceptable for pilots for short-term antifungal treatment. No significant CNS effects at standard doses. The underlying condition should not impair flight safety.

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Pilot Tip

Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.

Certification Details

Key Requirements
No significant side effects
Certificate Classes
All classes eligible
Notes
Short-term use straightforward; chronic use may prompt questions

Sources

  • FAA AME Guide, Pharmaceuticals

Last verified: 2026-03-01

Frequently Asked Questions

Is Fluconazole allowed for pilots?

The FAA considers Fluconazole (Diflucan) to be "Generally Approved" for medical certification purposes. Fluconazole is generally acceptable for pilots for short-term antifungal treatment. No significant CNS effects at standard doses. The underlying condition should not impair flight safety.

What is the FAA status of Fluconazole?

Fluconazole has a status of "Generally Approved" under FAA medical certification policy. The certification pathway is: Generally acceptable for short-term use.

Can I fly while taking Fluconazole?

Fluconazole is generally compatible with flying. However, you must report it on your FAA medical application (Form 8500-8) and ensure you are not experiencing side effects that could impair flight safety. Always consult your Aviation Medical Examiner (AME).

Important Notice

The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.

The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.