Sulfonylurea (Type 2 Diabetes)Conditionally Approved

Glimepiride

Brand names: Amaryl|Last verified: 2026-09-12

FAA Pathway: Special Issuance (Diabetes Mellitus — medication controlled); AME must defer initial certification

Glimepiride (Amaryl) is a sulfonylurea on the FAA's list of acceptable diabetes medications, but diabetes treated with any medication requires an Authorization for Special Issuance. The FAA makes the initial decision and the AME must defer. Sulfonylureas carry the FAA's longest non-insulin observation period: 60 days after starting.

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Related Resources

Pilot Tip

Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.

Certification Details

Initial Certification

FAA decision — the AME must defer

Observation Time

60 days after starting or adding it to an established regimen; 7 days after a dose or formulation change

Required Documents

Diabetes or Hyperglycemia on Medications Status Report (or detailed clinical progress note no more than 90 days old) plus an A1C within 90 days and at least 30 days after any medication change

Initial Target

A1C below 9.0 on an acceptable medication combination

Combinations

Up to 3 non-insulin medications, only one per group; this medication is Group A2

Certificate Classes

1st, 2nd, and 3rd class via Special Issuance

Sources

FAA AME Guide — Pharmaceuticals: Acceptable Combinations of Diabetes Medications (faa.gov/ame_guide/media/diabetesmeds_acceptablecomb.pdf)
FAA Protocol — Diabetes Mellitus Treated with Medication Other Than Insulin (faa.gov/ame_guide/dec_cons/disease_prot/diabetes_med)

Last verified: 2026-09-12

Frequently Asked Questions

Is Glimepiride allowed for pilots?

The FAA considers Glimepiride (Amaryl) to be "Conditionally Approved" for medical certification purposes. Glimepiride (Amaryl) is a sulfonylurea on the FAA's list of acceptable diabetes medications, but diabetes treated with any medication requires an Authorization for Special Issuance. The FAA makes the initial decision and the AME must defer. Sulfonylureas carry the FAA's longest non-insulin observation period: 60 days after starting.

What is the FAA status of Glimepiride?

Glimepiride has a status of "Conditionally Approved" under FAA medical certification policy. The certification pathway is: Special Issuance (Diabetes Mellitus — medication controlled); AME must defer initial certification.

Can I fly while taking Glimepiride?

Flying while taking Glimepiride may be possible through the FAA's Special Issuance process. You will need to meet specific requirements and obtain approval before exercising pilot privileges. Consult an experienced AME for guidance.

Important Notice

The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.

The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.