Sulfonylurea (Type 2 Diabetes)Conditionally Approved

Glipizide

Brand names: Glucotrol|Last verified: 2026-03-01

FAA Pathway: Special Issuance (Diabetes Protocol)

Glipizide is conditionally approved for pilots with Type 2 diabetes. Because sulfonylureas can cause hypoglycemia, the FAA requires additional glucose monitoring documentation compared to metformin alone.

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Pilot Tip

Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.

Certification Details

Key Requirements

Glucose log showing no hypoglycemic episodes, A1C monitoring

Certificate Classes

1st, 2nd, and 3rd class eligible

Hypoglycemia Risk

Higher than metformin — additional monitoring required

Typical Timeline

3–5 months for initial certification

Sources

FAA AME Guide — Pharmaceuticals: Diabetes Type II (faa.gov/ame_guide/pharm/oral_diabetes)

Last verified: 2026-03-01

Frequently Asked Questions

Is Glipizide allowed for pilots?

The FAA considers Glipizide (Glucotrol) to be "Conditionally Approved" for medical certification purposes. Glipizide is conditionally approved for pilots with Type 2 diabetes. Because sulfonylureas can cause hypoglycemia, the FAA requires additional glucose monitoring documentation compared to metformin alone.

What is the FAA status of Glipizide?

Glipizide has a status of "Conditionally Approved" under FAA medical certification policy. The certification pathway is: Special Issuance (Diabetes Protocol).

Can I fly while taking Glipizide?

Flying while taking Glipizide may be possible through the FAA's Special Issuance process. You will need to meet specific requirements and obtain approval before exercising pilot privileges. Consult an experienced AME for guidance.

Important Notice

The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.

The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.