DPP-4 Inhibitor (Type 2 Diabetes)Generally Approved

Linagliptin

Brand names: Tradjenta|Last verified: 2026-03-01

FAA Pathway: Standard issuance by AME for well-controlled Type 2 diabetes

Linagliptin is a DPP-4 inhibitor acceptable for FAA certification. Low hypoglycemia risk and no renal dose adjustment needed. Report on your application with diabetes documentation.

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Pilot Tip

Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.

Certification Details

Key Requirements
A1C controlled, no hypoglycemic episodes
Certificate Classes
All classes eligible
Hypoglycemia Risk
Low as monotherapy
Notes
No renal adjustment — favorable for pilots with mild renal impairment

Sources

  • FAA AME Guide — Pharmaceuticals: Diabetes Type II (faa.gov/ame_guide/pharm/oral_diabetes)

Last verified: 2026-03-01

Frequently Asked Questions

Is Linagliptin allowed for pilots?

The FAA considers Linagliptin (Tradjenta) to be "Generally Approved" for medical certification purposes. Linagliptin is a DPP-4 inhibitor acceptable for FAA certification. Low hypoglycemia risk and no renal dose adjustment needed. Report on your application with diabetes documentation.

What is the FAA status of Linagliptin?

Linagliptin has a status of "Generally Approved" under FAA medical certification policy. The certification pathway is: Standard issuance by AME for well-controlled Type 2 diabetes.

Can I fly while taking Linagliptin?

Linagliptin is generally compatible with flying. However, you must report it on your FAA medical application (Form 8500-8) and ensure you are not experiencing side effects that could impair flight safety. Always consult your Aviation Medical Examiner (AME).

Important Notice

The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.

The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.