Proton Pump Inhibitor (OTC)Generally Approved

Omeprazole (OTC)

Brand names: Prilosec OTC|Last verified: 2026-03-01

FAA Pathway: Generally acceptable — report on Form 8500-8

OTC omeprazole is acceptable for pilots, same as prescription omeprazole. Report even OTC medications on your application. The underlying GERD should be well-controlled.

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Related Resources

Pilot Tip

Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.

Certification Details

Key Requirements

Stable GI condition

Certificate Classes

All classes eligible

Notes

Even OTC medications should be reported on Form 8500-8

Sources

FAA OTC Medication Guide

Last verified: 2026-03-01

Frequently Asked Questions

Is Omeprazole (OTC) allowed for pilots?

The FAA considers Omeprazole (OTC) (Prilosec OTC) to be "Generally Approved" for medical certification purposes. OTC omeprazole is acceptable for pilots, same as prescription omeprazole. Report even OTC medications on your application. The underlying GERD should be well-controlled.

What is the FAA status of Omeprazole (OTC)?

Omeprazole (OTC) has a status of "Generally Approved" under FAA medical certification policy. The certification pathway is: Generally acceptable — report on Form 8500-8.

Can I fly while taking Omeprazole (OTC)?

Omeprazole (OTC) is generally compatible with flying. However, you must report it on your FAA medical application (Form 8500-8) and ensure you are not experiencing side effects that could impair flight safety. Always consult your Aviation Medical Examiner (AME).

Important Notice

The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.

The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.