Oxymetazoline (Nasal Spray)
Brand names: Afrin|Last verified: 2026-09-12
FAA Pathway: Acceptable — 48-hour ground trial when first used; no post-dose wait
The FAA lists oxymetazoline nasal spray (Afrin) as an acceptable decongestant. Wait 48 hours after your first use to confirm you have no side effects; after that, no wait is required after each dose. Decongestants can speed up your heart rate, so use caution if you have a heart condition. Don't fly if congestion keeps you from clearing your ears at ground level.
Pilot Tip
Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.
Certification Details
Sources
- FAA AME Guide — Pharmaceuticals: Allergy – Antihistamine & Immunotherapy (faa.gov/ame_guide/media/AllergyAntihistamineImmunotherapyMedication.pdf)
- FAA Pilot OTC Medications Reference Guide (faa.gov/pilots/medical_certification/media/OTCMedicationsforPilots.pdf)
Last verified: 2026-09-12
Frequently Asked Questions
Is Oxymetazoline (Nasal Spray) allowed for pilots?
The FAA considers Oxymetazoline (Nasal Spray) (Afrin) to be "Generally Approved" for medical certification purposes. The FAA lists oxymetazoline nasal spray (Afrin) as an acceptable decongestant. Wait 48 hours after your first use to confirm you have no side effects; after that, no wait is required after each dose. Decongestants can speed up your heart rate, so use caution if you have a heart condition. Don't fly if congestion keeps you from clearing your ears at ground level.
What is the FAA status of Oxymetazoline (Nasal Spray)?
Oxymetazoline (Nasal Spray) has a status of "Generally Approved" under FAA medical certification policy. The certification pathway is: Acceptable — 48-hour ground trial when first used; no post-dose wait.
Can I fly while taking Oxymetazoline (Nasal Spray)?
Oxymetazoline (Nasal Spray) is generally compatible with flying. However, you must report it on your FAA medical application (Form 8500-8) and ensure you are not experiencing side effects that could impair flight safety. Always consult your Aviation Medical Examiner (AME).
Important Notice
The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.
The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.