Paroxetine
Brand names: Paxil, Pexeva|Last verified: 2026-09-12
FAA Pathway: Unacceptable — listed by the FAA as an unacceptable antidepressant
Paroxetine (Paxil) is an SSRI, but the FAA's Antidepressant Medications table lists it as unacceptable, alone or in any combination product, so it cannot be used under the Antidepressant Protocol. Nine other antidepressants are conditionally acceptable. Never stop or switch medication on your own — talk with your psychiatrist and a HIMS AME, and expect to need 3 months of stability on any new medication.
Related Resources
Pilot Tip
Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.
Certification Details
Sources
- FAA AME Guide — Pharmaceuticals: Antidepressants (faa.gov/ame_guide/pharm/antidepressants)
- FAA AME Guide — Pharmaceuticals: Antidepressant Medications (faa.gov/ame_guide/media/Antidepressant_Medications.pdf)
Last verified: 2026-09-12
Frequently Asked Questions
Is Paroxetine allowed for pilots?
The FAA considers Paroxetine (Paxil, Pexeva) to be "Disqualifying" for medical certification purposes. Paroxetine (Paxil) is an SSRI, but the FAA's Antidepressant Medications table lists it as unacceptable, alone or in any combination product, so it cannot be used under the Antidepressant Protocol. Nine other antidepressants are conditionally acceptable. Never stop or switch medication on your own — talk with your psychiatrist and a HIMS AME, and expect to need 3 months of stability on any new medication.
What is the FAA status of Paroxetine?
Paroxetine has a status of "Disqualifying" under FAA medical certification policy. The certification pathway is: Unacceptable — listed by the FAA as an unacceptable antidepressant.
Can I fly while taking Paroxetine?
Paroxetine is currently disqualifying for FAA medical certification. You cannot fly while taking this medication. A washout period and evaluation are typically required after discontinuation. Consult an AME or aviation attorney before making any medication changes.
Important Notice
The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.
The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.