Trimethoprim-Sulfamethoxazole
Brand names: Bactrim, Septra|Last verified: 2026-03-01
FAA Pathway: Generally acceptable — underlying infection must not impair flight
TMP-SMX (Bactrim) is generally acceptable for pilots. The underlying urinary tract or other infection is the primary concern. Ensure adequate hydration and no significant side effects before flying.
Pilot Tip
Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.
Certification Details
Sources
- FAA AME Guide, Pharmaceuticals
Last verified: 2026-03-01
Frequently Asked Questions
Is Trimethoprim-Sulfamethoxazole allowed for pilots?
The FAA considers Trimethoprim-Sulfamethoxazole (Bactrim, Septra) to be "Generally Approved" for medical certification purposes. TMP-SMX (Bactrim) is generally acceptable for pilots. The underlying urinary tract or other infection is the primary concern. Ensure adequate hydration and no significant side effects before flying.
What is the FAA status of Trimethoprim-Sulfamethoxazole?
Trimethoprim-Sulfamethoxazole has a status of "Generally Approved" under FAA medical certification policy. The certification pathway is: Generally acceptable — underlying infection must not impair flight.
Can I fly while taking Trimethoprim-Sulfamethoxazole?
Trimethoprim-Sulfamethoxazole is generally compatible with flying. However, you must report it on your FAA medical application (Form 8500-8) and ensure you are not experiencing side effects that could impair flight safety. Always consult your Aviation Medical Examiner (AME).
Important Notice
The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.
The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.